- Title
- Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity
- Creator
- Sena, Carla Rebeca Da Silva; Morten, Matthew; Karmaus, Wilfried; Gibson, Peter G.; Robinson, Paul D.; Mattes, Joerg; Collison, Adam M.; Shaar, Aida; Andrade, Ediane de Queiroz; Meredith, Joseph; Kepreotes, Elizabeth; Murphy, Vanessa E.; Sly, Peter D.; Whitehead, Bruce
- Relation
- NHMRC.APP1081667 http://purl.org/au-research/grants/nhmrc/1081667
- Relation
- Pediatric Pulmonology Vol. 59, Issue 3, p. 632-641
- Publisher Link
- http://dx.doi.org/10.1002/ppul.26793
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2024
- Description
- Background: Rhinovirus (RV) positive bronchiolitis episodes in infancy confer a higher risk to develop asthma in later childhood with associated lung function impairments. We aimed to investigate the association between the type of virus causing a bronchiolitis hospitalization episode and lung ventilation inhomogeneities at preschool age. Methods: Infants hospitalized with a clinical diagnosis of moderate (ward admission) or severe (pediatric intensive care ward admission) bronchiolitis were prospectively followed-up at preschool age to assess nitrogen (N2 ) multiple breath washout (MBW). Lung clearance index (LCI), functional residual capacity (FRC), and concentration normalized phase III slope analysis (SnIII ) indices were reported from ≥2 technically acceptable trials. Differences between groups were calculated using logistic and linear regression and adjusted for confounders (sex, age at bronchiolitis admission, height at visit, maternal asthma, and doctor-diagnosed asthma, including interaction terms between the latter three). An interaction term was included in a regression model to test for an interaction between RV bronchiolitis severity and MBW parameters at preschool age. Results: One hundred and thirty-nine subjects attended preschool follow-up, of which 84 out of 103 (82%) performing MBW had technically acceptable data. Children with a history of RV positive bronchiolitis (n = 39) had increased LCI (adjusted β-coefficient [aβ] = 0.33, 95% confidence interval [CI] 0.02-0.65, p = 0.040) and conductive airways ventilation inhomogeneity [Scond ] (aβ = 0.016, CI 0.004-0.028, p = 0.011) when compared with those with a RV negative bronchiolitis history (n = 45). In addition, we found a statistical interaction between RV bronchiolitis and bronchiolitis severity strengthening the association with LCI (aβ = 0.93, CI 0.20-1.58, p = 0.006). Conclusion: Children with a history of hospital admission for RV positive bronchiolitis in infancy might be at a higher risk of lung ventilation inhomogeneities at preschool age, arising from the peripheral conducting airways.
- Subject
- multiple breath nitrogen washout; preschool children; rhinovirus; ventilation inhomogeneity; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1498951
- Identifier
- uon:54571
- Identifier
- ISSN:8755-6863
- Rights
- © 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Language
- eng
- Full Text
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